Reactive hyperemia in arterioles and capillaries of frog skeletal muscle following microocclusion.
نویسندگان
چکیده
We studied the localization of blood flow control in skeletal muscle by shortterm microocclusions (30-60 seconds) of capillaries and arterioles of the pectoralis muscle in anesthetized frogs (Rana pipiens). The muscle was surgically exposed to permit transillumination and measurement of red cell velocity in the microvessels, but innervation and blood supply were kept intact. About one-third of the arterioles showed postocclusion hyperemia. In some muscles every arteriole showed hyperemia following occlusion, but in others none responded, presumably because of preparatory trauma. The average duration of hyperemia after a 1-minute occlusion was 74 ± 45 (sx>) seconds. We also compared the effectiveness of arteriolar and capillary occlusions in producing reactive hyperemia in capillaries. Peak capillary blood flow after occlusion of the supply arteriole was 233% above control, and flow debt repayment was 278%. After occlusion of several capillaries, peak capillary blood flow was 67% above control, and flow debt repayment was 74%. In an individual capillary, peak blood flow after occlusion of that capillary was 15% above control, and flow debt repayment was 13%. In a majority of instances there was no discernible reactive hyperemia with single capillary occlusion. The results do not support the concept that flow in individual capillaries is regulated in accordance with each capillary's metabolic environment. Rather, flow in a capillary appears to depend on the metabolic environment of the arteriole supplying that capillary.
منابع مشابه
Reactive hyperemia in individual capillaries of skeletal muscle.
BURTON, K.. S., AND P. C. JOHNSON. Reactive hyperemia in individual capillaries of skeletal muscle. Am. J. Physiol. 223 (3) : 517-524. 1972.-Red cell velocity profiles in individual capillaries were studied in the sartorius muscle of the cat during reactive hyperemia using a dual-slit photometric system. The velocity profiles varied considerably from each other and from the simultaneously measu...
متن کاملStimulation of arteriogenesis in skeletal muscle by microbubble destruction with ultrasound.
BACKGROUND The application of ultrasound to microbubbles in skeletal muscle creates capillary ruptures. We tested the hypothesis that this bioeffect could be used to stimulate the growth and remodeling of new arterioles via natural repair processes, resulting in an increase in skeletal muscle nutrient blood flow. METHODS AND RESULTS Pulsed ultrasound (1 MHz) was applied to exposed rat gracili...
متن کاملMicrovascular remodeling and accelerated hyperemia blood flow restoration in arterially occluded skeletal muscle exposed to ultrasonic microbubble destruction.
We showed previously that microbubble destruction with pulsed 1-MHz ultrasound creates a bioeffect that stimulates arteriogenesis and a chronic increase in hyperemia blood flow in normal rat muscle. Here we tested whether ultrasonic microbubble destruction can be used to create a microvascular remodeling response that restores hyperemia blood flow to rat skeletal muscle affected by arterial occ...
متن کاملRole of resistance and exchange vessels in local microvascular control of skeletal muscle oxygenation in the dog.
The effects of reduction in perfusion pressure, arterial hypoxia, muscle contraction, and adrenergic stimulation on the hindlimb muscle circulation were studied. Under normal conditions (venous PO2 greater than or equal to 40 mm Hg), oxygen delivery to the muscle was maintained mainly by large increases in the capillary exchange capacity and the oxygen extraction ratio in accord with tissue dem...
متن کاملEffect of occlusion duration on reactive hyperemia in sartorius muscle capillaries.
Reactive hyperemia was studied in cat sartorius muscle by measurement of venous outflow and capillary red cell velocity following occlusions of 5-120 s. The peak value for volume flow rose in a graded manner as occlusion duration increased, reaching a level of 280% above control following 120 s of occlusion. By contrast, peak values for capillary flow were 200% above control even after short (1...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Circulation research
دوره 31 6 شماره
صفحات -
تاریخ انتشار 1972